Welkom‎ > ‎Wetenschap‎ > ‎Inwendige geneeskunde‎ > ‎Immunologie‎ > ‎2018‎ > ‎

CFS,CFDIS,...A review of contemporary scientific literature and suggested directions for future research





Chronic Fatigue and Immune Deficiency Syndrome (CFIDS), cellular metabolism, and ionizing radiation: A review of contemporary scientific literature and suggested directions for future research 


Andrej Rusin(1,*), Colin Seymour(2), Carmel Mothersill(3)

1 McMaster University, Biology, Hamilton, Ontario, Canada

2 McMaster University, Medical Physics and Applied Radiation   Sciences, Hamilton , Ontario, Canada

3 McMaster University, Biology, 1280 Main street West, Hamilton,   Ontario, Canada.


ABSTRACT:

Purpose

To investigate biochemical pathways known to be involved in radiation response and in CFIDS to determine if there might be common underlying mechanisms leading to symptoms experienced by those accidentally or deliberately exposed to radiation and those suffering from CFIDS. If such a link were established, to suggest testable hypotheses to investigate the mechanisms with the aim of identifying new therapeutic targets.

Conclusions

Evidence for involvement of the alpha-synuclein, cytochrome c oxidiase, αB-crystallin, RNase L, and lactate dehydrogenase/STAT1 pathways is strong and suggests a common underlying mechanism involving mitochondrial dysfunction mediated by ROS and disruption of ATP production. The downstream effect of this is compromised energy production. Testable hypotheses are suggested to investigate the  involvement of these pathways further.




Source:  International Journal of Radiation Biology (January 2018, pp 1-63)
Date: 3 januari 2018






CheckStat